Case Series of Isolated Deep Gray Matter Injuries in Preterm Infants

Hypoxic-ischemic encephalopathy in neonates is an important cause of brain damage that leads to severe neurological sequelae or death. Brain injury patterns on magnetic resonance imaging (MRI) scans are used predict neurodevelopmental outcome severity. This case series describes the clinical manifestations and neurologic outcomes four preterm infants with isolated deep gray matter injuries. Basal ganglia thalamic lesions were noted without white cerebral cortex lesion MRI. All patients born at less than 33 weeks’ gestation required resuscitation delivery room. had seizures during neonatal period requiring anti-seizure medications. Severe disability was identified three using assessment tools. Another patient has not been evaluated tools yet as he 2 months’ corrected age, but supported by home ventilation via a tracheostomy due insufficient self-respiration. demonstrates injuries could outcomes.